Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells
- PMID: 2893611
- DOI: 10.1016/0006-291x(88)90449-4
Modulation of c-myc by transforming growth factor-beta in human colon carcinoma cells
Abstract
Previous work indicated that transforming growth factor-beta elicits proliferation-inhibitory and differentiation-like effects in the human colon carcinoma cell line MOSER. We report for the first time that the proto-oncogene c-myc is repressed in response to transforming growth factor-beta in a human colon carcinoma cell line. We also describe a subline of these cells which are relatively resistant to the transforming growth factor-beta-induced effects on proliferation in monolayer and in soft agarose, but which retain the ability to specifically bind transforming growth factor-beta. Analysis of molecular and cellular alterations in this subline may aid in elucidating the mechanism of action of transforming growth factor-beta.
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