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Review
. 2017 Sep 7:11:493.
doi: 10.3389/fnins.2017.00493. eCollection 2017.

The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence

Giuliana S Zuccoli  1   2 , Verônica M Saia-Cereda  1   2 , Juliana M Nascimento  1   2 , Daniel Martins-de-Souza  1   2
Affiliations
Review

The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence

Giuliana S Zuccoli et al. Front Neurosci. .

Abstract

Psychiatric disorders represent a great medical and social challenge and people suffering from these conditions face many impairments regarding personal and professional life. In addition, a mental disorder will manifest itself in approximately one quarter of the world's population at some period of their life. Dysfunction in energy metabolism is one of the most consistent scientific findings associated with these disorders. With this is mind, this review compiled data on disturbances in energy metabolism found by proteomic analyses of postmortem brains collected from patients affected by the most prevalent psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD). We searched in the PubMed database to gather the studies and compiled all the differentially expressed proteins reported in each work. SCZ studies revealed 92 differentially expressed proteins related to energy metabolism, while 95 proteins were discovered in BPD, and 41 proteins in MDD. With the compiled data, it was possible to determine which proteins related to energy metabolism were found to be altered in all the disorders as well as which ones were altered exclusively in one of them. In conclusion, the information gathered in this work could contribute to a better understanding of the impaired metabolic mechanisms and hopefully bring insights into the underlying neuropathology of psychiatric disorders.

Keywords: bipolar disorder; depression; mass spectrometry; proteome; schizophrenia.

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Figures

Figure 1
Figure 1
Venn diagram evidencing peculiarities and similarities among the major psychiatric disorders.
Figure 2
Figure 2
Schematic representation of the altered proteins in SCZ, BPD, and MDD. Color from each disorder and combination of disorders correlates with the Venn diagram (Figure 1). GAPDH, Glyceraldehyde 3-phosphate dehydrogenase; PFK1, Phosphofructokinase 1; PGAM, Phosphoglycerate mutase; PGI, Phosphoglucose isomerase; PGK1, Phosphoglycerate kinase 1; PRX, Peroxiredoxin; SOD, Superoxide dismutase; TPI, Triosephosphate isomerase.
See this image and copyright information in PMC

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