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Review
. 2017 Sep;5(17):343.
doi: 10.21037/atm.2017.07.17.

Ex vivo lung perfusion review of a revolutionary technology

George Makdisi  1 , Tony Makdisi  2 , Tambi Jarmi  3 , Christiano C Caldeira  1
Affiliations
Review

Ex vivo lung perfusion review of a revolutionary technology

George Makdisi et al. Ann Transl Med. 2017 Sep.

Abstract

Donor lung shortage has been the main reason to the increasing number of patients waiting for lung transplant. Ex vivo lung perfusion (EVLP) is widely expanding technology to assess and prepare the lungs who are considered marginal for transplantation. the outcomes are encouraging and comparable to the lungs transplanted according to the standard criteria. in this article, we will discuss the history of development, the techniques and protocols of ex vivo, and the logics and rationales for ex vivo use.

Keywords: Ex vivo lung perfusion (EVLP); ex vivo; lung reconditioning; lung transplant.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
EVLP circuit with permission of Makdisi and Wozniak (33). O2, oxygen; CO2, carbon dioxide; N2, nitrogen; EVLP, ex vivo lung perfusion.
Figure 2
Figure 2
Lungs assessed by EVLP (Toronto protocol). EVLP, ex vivo lung perfusion.
See this image and copyright information in PMC

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