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. 2017 Aug;3(8):e428.

The role of corneal stroma: A potential nutritional source for the cornea

Lingling Zhang  1 , Matthew C Anderson  1 , Chia-Yang Liu  1
Affiliations

The role of corneal stroma: A potential nutritional source for the cornea

Lingling Zhang et al. J Nat Sci. 2017 Aug.

Abstract

Corneal stroma plays a pivotal role in normal visual function. Anatomically, it is located between the outer epithelium and the inner endothelium and is the thickest layer of the cornea. Keratocytes in the stroma produce a variety of cellular products, including growth factors/cytokines, extracellular matrix (ECM) components, and kinases. These products support normal corneal development and homeostasis.

Keywords: Corneal Stroma; Cytokines; Extracellular Matrix; Keratocytes; Kinases.

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Conflict of interest statement

Conflict of Interest: No conflicts declared.

References

    1. Zhang Y, Yeh LK, Zhang S, Call M, Yuan Y, Yasunaga M, Kao WW, Liu CY. Wnt/beta-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development. Development. 2015;142:3383–3393. - PMC - PubMed
    1. Wilson SE, Chen L, Mohan RR, Liang Q, Liu J. Expression of HGF, KGF, EGF and receptor messenger RNAs following corneal epithelial wounding. Exp Eye Res. 1999;68:377–397. - PubMed
    1. Carrington LM, Boulton M. Hepatocyte growth factor and keratinocyte growth factor regulation of epithelial and stromal corneal wound healing. J Cataract Refract Surg. 2004;31:412–423. - PubMed
    1. Weng J, Mohan R, Li Q, Wilson S. IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: interleukin-1 beta expression in the cornea. Cornea. 1997;16:465–471. - PubMed
    1. Sun M, Chen S, Adams SM, Florer JB, Liu H, Kao WW, Wenstrup RJ, Birk DE. Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model. J Cell Sci. 2011;124:4096–4105. - PMC - PubMed

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