Prevalence of abdominal artery calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis

Abstract

Purpose: To systematically determine the prevalence of abdominal artery calcification (AAC) in dialysis patients with end-stage renal disease (ESRD) and identify reasons for heterogeneity.

Methods: We searched PubMed, EMBASE, and Web of Science from database inception to March 2017. Cross-sectional or cohort (only used baseline data) studies reporting estimates of AAC prevalence in dialysis adult patients with ESRD were included. We performed a random-effects meta-analysis to generate pooled prevalence estimates. Subgroup analyses were used to compare differences within categorical variables (geographic region, AAC detection instruments, dialysis methods, study design, and sample size), and meta-regression analyses to assess the impact of continuous variables (participants' age, duration of dialysis, and male proportion).

Results: A total of 44 studies with 9883 dialysis patients were included. The pooled prevalence for AAC was 68.5% (95% CI 63-73.9%). Subgroup analyses suggested that AAC prevalence varied significantly by geographical region and AAC detection instruments, not by dialysis methods, study design and sample size. Meta-regression analysis suggested that positive correlations were found between AAC prevalence and the age of participants as well as the male proportion (r = 1.01477, P = 0.002 and r = 2.034413, P = 0.01, respectively), but not with the duration of dialysis (P = 0.576).

Conclusion: The pooled and nearest estimate of AAC prevalence among dialysis patients was as high as 65%. Geographical region, AAC detection instruments, age of participants, and male proportion potentially lead to the high variance of the reported prevalence. Considering the high AAC prevalence, effective treatment for preventing vascular calcification in these patients is badly needed.

Keywords: Abdominal artery calcification; Dialysis; End-stage renal disease; Meta-analysis; Prevalence.