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Review
. 2017 Oct;33(5):585-597.
doi: 10.1007/s12264-017-0183-5. Epub 2017 Sep 21.

Biomarkers for Parkinson's Disease: Recent Advancement

Sharvari Lotankar  1 , Kedar S Prabhavalkar  2 , Lokesh K Bhatt  1
Affiliations
Review

Biomarkers for Parkinson's Disease: Recent Advancement

Sharvari Lotankar et al. Neurosci Bull. 2017 Oct.

Abstract

As a multi-factorial degenerative disease, Parkinson's disease (PD) leads to tremor, gait rigidity, and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible. Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid, oxidative stress, neuroprotection, and inflammation. Also, biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development.

Keywords: Biochemical biomarkers; Clinical biomarkers; Genetic biomarkers; Imaging biomarkers; Parkinson’s disease.

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References

    1. Frisardi V, Santamato A, Cheeran B. Parkinson’s disease: new insights into pathophysiology and rehabilitative approaches. Parkinson’s Dis. 2016;2016:3121727. - PMC - PubMed
    1. Mazzoni P, Shabbott B, Cortés JC. Motor control abnormalities in Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a009282. - PMC - PubMed
    1. Teive HA, Bertucci Filho DC, Munhoz RP. Unusual motor and non-motor symptoms and signs in the early stage of Parkinson’s disease. Arquivos de Neuro-Psiquiatria. 2016;74:781–784. - PubMed
    1. Miki Y, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K. PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson’s disease. Neurosci Lett. 2017;645:40–45. - PubMed
    1. Gupta R, Kim C, Agarwal N, Lieber B, Monaco EA. Understanding the influence of Parkinson disease on Adolf Hitler’s decision-making during World War II. World Neurosurg. 2015;84:1447–1452. - PubMed