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Review
. 2017 Sep 22;18(10):2030.
doi: 10.3390/ijms18102030.

Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation

Shu-Yi Lin  1 , Hui-Wen Chen  2   3
Affiliations
Review

Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation

Shu-Yi Lin et al. Int J Mol Sci. .

Abstract

Infectious bronchitis virus (IBV) variants constantly emerge and pose economic threats to poultry farms worldwide. Numerous studies on the molecular and pathogenic characterization of IBV variants have been performed between 2007 and 2017, which we have reviewed herein. We noted that viral genetic mutations and recombination events commonly gave rise to distinct IBV genotypes, serotypes and pathotypes. In addition to characterizing the S1 genes, full viral genomic sequencing, comprehensive antigenicity, and pathogenicity studies on emerging variants have advanced our understanding of IBV infections, which is valuable for developing countermeasures against IBV field outbreaks. This review of IBV variants provides practical value for understanding their phylogenetic relationships and epidemiology from both regional and worldwide viewpoints.

Keywords: antigenicity; genotypes; infectious bronchitis virus; pathogenicity; variants.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Phylogenetic analysis of the complete S1 gene of the IBV variants reviewed in this study and reference strains. The phylogenetic tree was constructed using MEGA version 6 by the neighbor-joining method (bootstrapping for 1000 replicates, bootstrap value >70%). CN: China; IT: Italy; KR: Korea; SE: Sweden; TW: Taiwan; US: United States.
Figure 2
Figure 2
Phylogenetic analysis of the full-length genome of the IBV variants reviewed in this study and reference strains. The strains with a symbol belong to the lineage with the same symbol when the S1 gene is analyzed. The phylogenetic tree was constructed using MEGA version 6 by the neighbor-joining method (bootstrapping for 1000 replicates, bootstrap value >70%). CN: China; IT: Italy; KR: Korea; SE: Sweden; TW: Taiwan; US: United States.
See this image and copyright information in PMC

References

    1. Schalk A., Hawn M. An apparently new respiratory disease of baby chicks. J. Am. Vet. Med. Assoc. 1931;78:413–422.
    1. Cavanagh D., Davis P.J., Mockett A.P.A. Amino-Acids within Hypervariable Region-1 of Avian Coronavirus Ibv (Massachusetts Serotype) Spike Glycoprotein Are Associated with Neutralization Epitopes. Virus Res. 1988;11:141–150. doi: 10.1016/0168-1702(88)90039-1. - DOI - PMC - PubMed
    1. Cavanagh D., Elus M.M., Cook J.K. Relationship between sequence variation in the S1 spike protein of infectious bronchitis virus and the extent of cross-protection in vivo. Avian Pathol. 1997;26:63–74. doi: 10.1080/03079459708419194. - DOI - PubMed
    1. Cavanagh D., Davis P.J. Coronavirus IBV: Removal of spike glycopolypeptide S1 by urea abolishes infectivity and haemagglutination but not attachment to cells. J. Gen. Virol. 1986;67:1443–1448. doi: 10.1099/0022-1317-67-7-1443. - DOI - PubMed
    1. Promkuntod N., Van Eijndhoven R., De Vrieze G., Gröne A., Verheije M. Mapping of the receptor-binding domain and amino acids critical for attachment in the spike protein of avian coronavirus infectious bronchitis virus. Virology. 2014;448:26–32. doi: 10.1016/j.virol.2013.09.018. - DOI - PMC - PubMed

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