Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jan;13(1):88-100.
doi: 10.1177/1745691617718356. Epub 2017 Sep 22.

Our (Mother's) Mitochondria and Our Mind

Affiliations
Review

Our (Mother's) Mitochondria and Our Mind

Peter Kramer et al. Perspect Psychol Sci. 2018 Jan.

Abstract

Most of the energy we get to spend is furnished by mitochondria, minuscule living structures sitting inside our cells or dispatched back and forth within them to where they are needed. Mitochondria produce energy by burning down what remains of our meal after we have digested it, but at the cost of constantly corroding themselves and us. Here we review how our mitochondria evolved from invading bacteria and have retained a small amount of independence from us; how we inherit them only from our mother; and how they are heavily implicated in learning, memory, cognition, and virtually every mental or neurological affliction. We discuss why counteracting mitochondrial corrosion with antioxidant supplements is often unwise, and why our mitochondria, and therefore we ourselves, benefit instead from exercise, meditation, sleep, sunshine, and particular eating habits. Finally, we describe how malfunctioning mitochondria force rats to become socially subordinate to others, how such disparity can be evened off by a vitamin, and why these findings are relevant to us.

Keywords: Alzheimer’s disease; Parkinson’s disease; aging; depression; free radicals; ketogenic diet; mitochondria.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The authors declared that they had no conflicts of interest with respect to their authorship or the publication of this article.

References

    1. Ahmad T., Aggarwal K., Pattnaik B., Mukherjee S., Sethi T., Tiwari B. K., . . . Agrawal A. (2013). Computational classification of mitochondrial shapes reflects stress and redox state. Cell Death and Disease, 4, e461. doi: 10.1038/cddis.2012.213 - DOI - PMC - PubMed
    1. Allen J. F. (1996). Separate sexes and the mitochondrial theory of ageing. Journal of Theoretical Biology, 180, 135–140. doi: 10.1006/jtbi.1996.0089 - DOI - PubMed
    1. Allen J. F., de Paula W. B. (2013). Mitochondrial genome function and maternal inheritance. Biochemical Society Transactions, 41, 1298–1304. doi: 10.1042/BST20130106 - DOI - PubMed
    1. Anglin R., Rosebush P., Mazurek M. (2012). Psychotropic medications and mitochondrial toxicity. Nature Reviews Neuroscience, 13, 650. - PubMed
    1. Arbuzova S., Hutchin T., Cuckle H. (2002). Mitochondrial dysfunction and Down’s syndrome. BioEssays, 24, 681–684. doi: 10.1002/bies.10138 - DOI - PubMed

LinkOut - more resources