Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Oct 18;16(20):1853-1854.
doi: 10.1080/15384101.2017.1372546. Epub 2017 Sep 22.

GAS2L3: Coordinator of cardiomyocyte cytokinesis?

Marco Gründl  1 , Felix B Engel  2 , Stefan Gaubatz  1
Affiliations
Editorial

GAS2L3: Coordinator of cardiomyocyte cytokinesis?

Marco Gründl et al. Cell Cycle. .
No abstract available

Keywords: GAS2L3; binucleation; cardiomyocytes; cell cycle; cytokinesis; p21CIP1.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic illustration of the heart phenotype of Gas2l3−/− mice, whereby loss of Gas2l3 leads to defects in cardiomyocyte cytokinesis resulting in premature binucleation, cell cycle arrest and cardiomyopathy. In a speculative model GAS2L3 coordinates cytokinesis of cardiomyocytes with the breakdown of sarcomeres. See text for details.
See this image and copyright information in PMC

Comment on

References

    1. Foglia MJ, Poss KD. Building and re-building the heart by cardiomyocyte proliferation. Development. 2016;143:729-40. doi:10.1242/dev.132910. PMID:26932668 - DOI - PMC - PubMed
    1. Stopp S, Gründl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, Eyss von B, Engel FB, Gaubatz S. Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci USA. 2017;114(30):8029-34. doi:10.1073/pnas.1703406114. PMID:28698371 - DOI - PMC - PubMed
    1. Wolter P, Schmitt K, Fackler M, Kremling H, Probst L, Hauser S, Gruss OJ, Gaubatz S. GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability. J Cell Sci. 2012;125:2393-406. doi:10.1242/jcs.097253. PMID:22344256 - DOI - PubMed
    1. Pe'er T, Lahmi R, Sharaby Y, Chorni E, Noach M, Vecsler M, Zlotorynski E, Steen H, Steen JA, Tzur A. Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C(Cdh1) complex. PLoS ONE. 2013;8:e57532. doi:10.1371/journal.pone.0057532. PMID:23469016 - DOI - PMC - PubMed
    1. Fackler M, Wolter P, Gaubatz S. The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission. FEBS J. 2014;281:2123-35. doi:10.1111/febs.12766. PMID:24571573 - DOI - PubMed

Substances

LinkOut - more resources