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Comment
. 2017 Sep 21;171(1):32-33.
doi: 10.1016/j.cell.2017.09.009.

Huntingtin Fibrils Poke Membranes

Pedro Guedes-Dias  1 , Erika L F Holzbaur  2
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Free article
Comment

Huntingtin Fibrils Poke Membranes

Pedro Guedes-Dias et al. Cell. .
Free article

Abstract

A hallmark of Huntington's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological significance of which has long been debated. Using cryo-electron tomography, Bauerlein et al. reveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils interact with the endoplasmic reticulum, distorting its morphology and dynamics.

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  • In Situ Architecture and Cellular Interactions of PolyQ Inclusions.
    Bäuerlein FJB, Saha I, Mishra A, Kalemanov M, Martínez-Sánchez A, Klein R, Dudanova I, Hipp MS, Hartl FU, Baumeister W, Fernández-Busnadiego R. Bäuerlein FJB, et al. Cell. 2017 Sep 21;171(1):179-187.e10. doi: 10.1016/j.cell.2017.08.009. Epub 2017 Sep 7. Cell. 2017. PMID: 28890085

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