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. 2017 Aug 2;8(35):59720-59728.
doi: 10.18632/oncotarget.19814. eCollection 2017 Aug 29.

APE1 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis

Chun-Ling Yuan  1 , Fan He  2 , Jia-Zhou Ye  3 , Hui-Ni Wu  4 , Jin-Yan Zhang  1 , Zhi-Hui Liu  1 , Yong-Qiang Li  1 , Xiao-Ling Luo  1 , Yan Lin  1 , Rong Liang  1
Affiliations

APE1 overexpression is associated with poor survival in patients with solid tumors: a meta-analysis

Chun-Ling Yuan et al. Oncotarget. .

Abstract

APE1 is known as a key mediator of DNA damage repair pathways, and its clinical significance in different types of cancer is well studied. Herein, we performed a meta-analysis to determine the association of APE1 expression and survival in different types of solid cancer. We searched all eligible publications in PubMed, Web of Science and Embase platforms from inception to January 2017 and found 15 relevant manuscripts. Overall survival (OS), 12- and 36-month survival rates, and hazard ratios (HRs) were extracted and analyzed. Heterogeneity and publication bias were also assessed. A subgroup analysis of the different subcellular locations of APE1 was also conducted. Patients with higher APE1 levels demonstrated lower 12- and 36-month survival rates than those with low APE1 levels (HR 2.00, 95% CI 1.33-3.00, P = 0.0009; HR 1.84, 95% CI 1.19-2.84, P = 0.006). Importantly, the pooled analysis showed that high levels of APE1 predict shorter OS (HR 1.44, 95% CI 1.13-1.83, P = 0.003). Subgroup analysis revealed that both nuclear and cytoplasmic expression levels of APE1 are important indicators of poor prognosis in solid tumors.

Keywords: APE1; IHC; meta-analysis; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors have no conflicts of interest to report.

Figures

Figure 1
Figure 1. Flow diagram of the literature search strategy in the meta-analysis
Figure 2
Figure 2
Forest plot (A) of the hazard ratio for the association of APE1 levels and OS; Begg's funnel plots of publication bias (B) for the meta-analysis of the hazard ratio for the association of APE1 levels and OS.
Figure 3
Figure 3. Subgroup analysis of APE1 nuclear/cytoplasmic expression and OS
Forest plot (A) of the hazard ratio for the association of nuclear-expressed APE1 levels and OS; Begg's funnel plots of publication bias (B) for meta-analysis of OS of high and low nuclear-expressed APE1; forest plot (C) of the hazard ratio for the association of cytoplasm-expressed APE1 levels and OS; Begg's funnel plots of publication bias (D) for meta-analysis of OS of high and low cytoplasm-expressed APE1.
Figure 4
Figure 4. Subgroup analysis of 1-year and 3-year survival rates and APE1 expression
Forest plot (A) of the hazard ratio for the association of APE1 levels and 1-year survival rate; Begg's funnel plots of publication bias (B) for meta-analysis of 1-year survival rate of high and low APE1 expression; forest plot (C) of the hazard ratio for the association of APE1 levels and 3-year OS; Begg's funnel plots of publication bias (D) for meta-analysis of 3-year survival rates of high and low APE1 expression.
See this image and copyright information in PMC

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