Preclinical evidence of ghrelin as a therapeutic target in epilepsy
- PMID: 28938694
- PMCID: PMC5601790
- DOI: 10.18632/oncotarget.18349
Preclinical evidence of ghrelin as a therapeutic target in epilepsy
Abstract
Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.
Keywords: epilepsy; ghrelin; hippocampus; memory; neuroprotection.
Conflict of interest statement
CONFLICTS OF INTEREST The authors confirm that this article content has no conflicts of interest.
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