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Comment
. 2017 Oct;92(4):782-784.
doi: 10.1016/j.kint.2017.04.036.

Foreseeing the future of glomerular disease through slits: miR-NPNT axis

Reiko Inagi  1 , Yu Ishimoto  2 , Tzu-Ming Jao  3
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Free article
Comment

Foreseeing the future of glomerular disease through slits: miR-NPNT axis

Reiko Inagi et al. Kidney Int. 2017 Oct.
Free article

Abstract

Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.

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