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. 2017 Sep 21;7(9):e016025.
doi: 10.1136/bmjopen-2017-016025.

Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting

Elena Argento  1   2 , Steffanie A Strathdee  3 , Kenneth Tupper  4   5 , Melissa Braschel  1 , Evan Wood  4   5 , Kate Shannon  1   4
Affiliations

Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting

Elena Argento et al. BMJ Open. .

Abstract

Objective: This study aimed to longitudinally investigate whether ever having used a psychedelic drug can have a protective effect on incidence of suicidality among marginalised women.

Design: Longitudinal community-based cohort study.

Setting: Data were drawn from a prospective, community-based cohort of marginalised women in Metro Vancouver, Canada.

Participants: 766 women completed the baseline questionnaire between January 2010 and August 2014. Participants who did not report suicidality at baseline and who completed at least one follow-up visit were included.

Main outcome measure: Extended Cox regression was used to model predictors of new suicidality (suicide ideation or attempts) over 54-month follow-up.

Results: Nearly half (46%; n=355) of participants reported prior suicidality and were thus excluded from the present analyses. Of 290 women eligible at baseline, 11% (n=31) reported recent suicidality during follow-up, with an incidence density of 4.42 per 100 person-years (95% CI 3.10 to 6.30). In multivariable analysis, reported lifetime psychedelic drug use was associated with a 60% reduced hazard for suicidality (adjusted HR (AHR) 0.40; 95% CI 0.17 to 0.94). Crystal methamphetamine use (AHR 3.25; 95% CI 1.47 to 7.21) and childhood abuse (AHR 3.54; 95% CI 1.49 to 8.40) remained independent predictors of suicidality.

Conclusion: The high rate of suicidality identified in this study is of major concern. Alongside emerging evidence on the potential of psychedelic-assisted therapy to treat some mental illness and addiction issues, our findings demonstrate that naturalistic psychedelic drug use is independently associated with reduced suicidality, while other illicit drug use and childhood trauma predispose women to suicidality. While observational, this study supports calls for further investigation of the therapeutic utility of psychedelic drugs in treating poor mental health and promoting mental wellness.

Keywords: hallucinogens; mental health; psychedelics; sex workers.

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Conflict of interest statement

Competing interests: All authors have completed the ICMJE uniform disclosure format www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work.

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