Metabolomics of Diabetic Retinopathy

Gerald Liew^{1

2}, Zhou Lei³, Gavin Tan³, Nichole Joachim⁴, I-Van Ho^{5

6

7}, Tien Y Wong³, Paul Mitchell⁴, Bamini Gopinath⁴, Ben Crossett⁸

Affiliations

¹ Centre for Vision Research, Westmead Millennium Institute of Medical Research, University of Sydney, Westmead, Sydney, 2145, Australia. gerald.liew@sydney.edu.au.
² South West Retina, Retina Associates, Liverpool, Sydney, Australia. gerald.liew@sydney.edu.au.
³ Duke-NUS School of Medicine, National University of Singapore, Singapore, Singapore.
⁴ Centre for Vision Research, Westmead Millennium Institute of Medical Research, University of Sydney, Westmead, Sydney, 2145, Australia.
⁵ South West Retina, Retina Associates, Liverpool, Sydney, Australia.
⁶ Save Sight Institute, University of Sydney, Sydney, Australia.
⁷ Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
⁸ Mass Spectrometry Core Facility, Building D17, University of Sydney, Sydney, Australia.

PMID: 28940103
DOI: 10.1007/s11892-017-0939-3

Review

Metabolomics of Diabetic Retinopathy

Gerald Liew et al. Curr Diab Rep. 2017.

. 2017 Sep 23;17(11):102.

doi: 10.1007/s11892-017-0939-3.

Authors

Gerald Liew^{1

2}, Zhou Lei³, Gavin Tan³, Nichole Joachim⁴, I-Van Ho^{5

6

7}, Tien Y Wong³, Paul Mitchell⁴, Bamini Gopinath⁴, Ben Crossett⁸

Affiliations

¹ Centre for Vision Research, Westmead Millennium Institute of Medical Research, University of Sydney, Westmead, Sydney, 2145, Australia. gerald.liew@sydney.edu.au.
² South West Retina, Retina Associates, Liverpool, Sydney, Australia. gerald.liew@sydney.edu.au.
³ Duke-NUS School of Medicine, National University of Singapore, Singapore, Singapore.
⁴ Centre for Vision Research, Westmead Millennium Institute of Medical Research, University of Sydney, Westmead, Sydney, 2145, Australia.
⁵ South West Retina, Retina Associates, Liverpool, Sydney, Australia.
⁶ Save Sight Institute, University of Sydney, Sydney, Australia.
⁷ Australian School of Advanced Medicine, Macquarie University, Sydney, Australia.
⁸ Mass Spectrometry Core Facility, Building D17, University of Sydney, Sydney, Australia.

PMID: 28940103
DOI: 10.1007/s11892-017-0939-3

Abstract

Purpose of review: Metabolomics is the study of dysregulated metabolites in biological materials. We reviewed the use of the technique to elucidate the genetic and environmental factors that contribute to the development of diabetic retinopathy.

Recent findings: With regard to metabolomic studies of diabetic retinopathy, the field remains in its infancy with few studies published to date and little replication of results. Vitreous and serum samples are the main tissues examined, and dysregulation in pathways such as the pentose phosphate pathway, arginine to proline pathway, polyol pathway, and ascorbic acidic pathways have been reported. Few studies have examined the metabolomic underpinnings of diabetic retinopathy. Further research is required to replicate findings to date and determine longitudinal associations with disease.

Keywords: Arginine; Ascorbic acid; Blood; Diabetic retinopathy; Metabolomics; Metabonomic.

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References

1. Cell Death Dis. 2014 Feb 20;5:e1075 - PubMed
1. JAMA Ophthalmol. 2014 Jan;132(1):96-107 - PubMed
1. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11300-5 - PubMed
1. Nature. 2016 Jul 21;535(7612):376-81 - PubMed
1. Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6 - PubMed

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Metabolomics of Diabetic Retinopathy

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Metabolomics of Diabetic Retinopathy

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