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Review
. 2017 Oct;30(5):671-675.
doi: 10.1007/s40620-017-0430-x. Epub 2017 Sep 23.

Vitamin D and osteoporosis in chronic kidney disease

Paul Lips  1 , David Goldsmith  2 , Renate de Jongh  3
Affiliations
Review

Vitamin D and osteoporosis in chronic kidney disease

Paul Lips et al. J Nephrol. 2017 Oct.

Abstract

Osteoporotic fractures are common in patients with chronic kidney disease (CKD). Morbidity and mortality are higher in CKD patients with a fracture than in the general population. The assessment of bone mineral density for fracture prediction may be useful at all CKD stages. It should be considered when this influences treatment decisions. Vitamin D deficiency is common in patients with CKD, particularly in patients with proteinuria, due to loss of 25-hydroxyvitamin D and its binding protein. Vitamin D supplementation should be prescribed early in the course of renal disease. For treatment and prevention of vitamin D deficiency in CKD patients cholecalciferol 800 IU/day or the equivalent per month is recommended just as in the general population.

Keywords: Bone mineral density; Chronic kidney disease; Osteoporosis; Vitamin D.

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Conflict of interest statement

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

For this review, informed consent from participants to clinical studies was not necessary. The review complies with the Helsinki code.

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