Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct;64(5):1039-1056.
doi: 10.1016/j.pcl.2017.06.005. Epub 2017 Aug 18.

Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm

Peter M Mourani  1 , Marci K Sontag  2
Affiliations
Review

Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm

Peter M Mourani et al. Pediatr Clin North Am. 2017 Oct.

Abstract

Ventilator-associated pneumonia (VAP) is a serious complication of critical illness. Surveillance definitions have undergone revisions for more objective and consistent reporting. The 1 organism-1 disease paradigm for microbial involvement may not adequately apply to many cases of VAP, in which pathogens are introduced to a pre-existing and often complex microbial community that facilitates or hinders the potential pathogen, consequently determining whether progression to VAP occurs. As omics technology is applied to VAP, a paradigm is emerging incorporating simultaneous assessments of microbial populations and their activity, as well as the host response, to personalize prevention and treatment.

Keywords: Mechanical ventilation; Metagenomics; Microbiome; Pediatric intensive care; Ventilator-associated pneumonia.

PubMed Disclaimer