Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec 14;36(51):7805-7810.
doi: 10.1016/j.vaccine.2017.08.092. Epub 2017 Sep 20.

Epidemiology of childhood intussusception in Bangladesh: Findings from an active national hospital based surveillance system, 2012-2016

Syed M Satter  1 , Negar Aliabadi  2 , Catherine Yen  2 , Paul A Gastañaduy  2 , Makhdum Ahmed  3 , Abdullah Mamun  4 , Khaleda Islam  5 , Meerjady S Flora  5 , Mahmudur Rahman  5 , K Zaman  6 , Mustafizur Rahman  6 , James D Heffelfinger  2 , Stephen P Luby  7 , Emily S Gurley  6 , Umesh D Parashar  2
Affiliations

Epidemiology of childhood intussusception in Bangladesh: Findings from an active national hospital based surveillance system, 2012-2016

Syed M Satter et al. Vaccine. .

Abstract

Introduction: Rotavirus vaccines have significantly decreased the burden of diarrheal diseases in countries that have introduced them into their immunization programs. In some studies, there has been a small association between rotavirus vaccines and intussusception in post-marketing surveillance, highlighting the importance of tracking incidence before and after vaccine introduction. The objective of this study was to describe the epidemiology of intussusception among Bangladeshi children pre-vaccine introduction.

Methods: We conducted active, hospital-based surveillance for intussusception at 7 tertiary care hospitals with pediatric surgical facilities during July 2012 to September 2016. Hospitalized children under 2years of age were identified according to Brighton Collaboration level 1 criteria for intussusception. The frequency and proportion of intussusception among overall surgical admissions, as well as the demographic and clinical information of the cases is described.

Results: Overall 153 cases of intussusception among children <2years-old were identified at participating sites over the enrolment period, confirmed by Level 1 Brighton criteria. These cases represented 2% of all surgical admissions under 2years of age. One hundred twelve cases (73%) were male; the median age was 7months; and the median duration of hospitalization was 7days. One hundred forty-six (95%) children with intussusception required surgery, and 11 (7%) died.

Conclusions: Confirmed cases of intussusception represented nearly 2% of pediatric surgical admissions at tertiary referral centers in Bangladesh during the study period and 7% of children with intussusception died. Given the high burden of rotavirus disease in Bangladesh, vaccine introduction is warranted, however, further studies after introduction of rotavirus vaccine are necessary to determine any association between vaccine and intussusception in this setting.

Keywords: Bangladesh; Hospital based surveillance; Intussusception; Rotavirus; Rotavirus vaccination.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest

There is no conflict of interest.

Figures

Fig. 1
Fig. 1
Locations of sentinel hospitals where intussusception surveillance was conducted in Bangladesh, July 2012–September 2016. H represents the location of hospital within each division.
Fig. 2
Fig. 2
Age distribution of Intussusception associated hospitalizations among children <2 years of age (N = 153) at 8 sentinel hospitals in Bangladesh, July 2012–September 2016.
Fig. 3
Fig. 3
Hospitalization by month for Intussusception (N = 153) among children aged <2 years at sentinel hospitals in Bangladesh, July 2012–September 2016.
See this image and copyright information in PMC

References

    1. Patel MM, Glass R, Desai R, Tate JE, Parashar UD. Fulfilling the promise of rotavirus vaccines: how far have we come since licensure? Lancet Infect Dis. 2012;12(7):561–70. - PubMed
    1. Jacqueline E, Tate AHB, Cynthia Boschi-Pinto, Parashar Umesh D for the World Health Organization–Coordinated Global Rotavirus, Network S. Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000–2013. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2016 in press. - PMC - PubMed
    1. Mpabalwani EM, Simwaka CJ, Mwenda JM, Mubanga CP, Monze M, Matapo B, et al. Impact of Rotavirus Vaccination on Diarrheal Hospitalizations in Children Aged <5 Years in Lusaka, Zambia. Clin Infect Dis: An Off Publ Infect Dis Soc Am. 2016;62(Suppl 2):S183–7. - PMC - PubMed
    1. Groome MJ, Zell ER, Solomon F, Nzenze S, Parashar UD, Izu A, et al. Temporal Association of Rotavirus Vaccine Introduction and Reduction in All-Cause Childhood Diarrheal Hospitalizations in South Africa. Clin Infect Dis: An Off Publ Infect Dis Soc Am. 2016;62(Suppl 2):S188–95. - PMC - PubMed
    1. Carlin JB, Macartney KK, Lee KJ, Quinn HE, Buttery J, Lopert R, et al. Intussusception risk and disease prevention associated with rotavirus vaccines in Australia’s National Immunization Program. Clin Infect Dis. 2013;57(10):1427–34. - PubMed

Publication types

Substances

LinkOut - more resources