A Yin and Yang in Epithelial Immunology: The Roles of the αE(CD103)β7 Integrin in T Cells

Abstract

The proper function(s) of cell-surface receptors is crucial for the regulation of adaptive immune responses. One such receptor is the α_E(CD103)β₇ integrin, whose history in science is closely linked with the evolution of our knowledge of immune regulation. Initially described as a marker of intraepithelial T-lymphocytes, this leukocyte integrin is now seen as a dynamically regulated receptor involved in the functional differentiation of some cytotoxic T cells as well as regulatory T cells, thus presumably contributing to the fine-tuning of immune reactions in epithelial compartments. In this brief overview, we delineate our current view on α_E(CD103)β₇ in T-cell-mediated immune responses.