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Review
. 2018 Jan:67:84-92.
doi: 10.1016/j.jbior.2017.09.005. Epub 2017 Sep 18.

MYO18A: An unusual myosin

Matthew D Buschman  1 , Seth J Field  2
Affiliations
Review

MYO18A: An unusual myosin

Matthew D Buschman et al. Adv Biol Regul. 2018 Jan.

Abstract

MYO18A is a divergent member of the myosin family characterized by the presence of an amino-terminal PDZ domain. MYO18A has been found in a few different complexes involved in intracellular transport processes. MYO18A is found in a complex with LURAP1 and MRCK that functions in retrograde treadmilling of actin. It also has been found in a complex with PAK2, βPIX, and GIT1, functioning to transport that protein complex from focal adhesions to the leading edge. Finally, a high proportion of MYO18A is found in complex with GOLPH3 at the trans Golgi, where it functions to promote vesicle budding for Golgi-to-plasma membrane trafficking. Interestingly, MYO18A has been implicated as a cancer driver, as have other components of the GOLPH3 pathway. It remains uncertain as to whether or not MYO18A has intrinsic motor activity. While many questions remain, MYO18A is a fascinatingly unique myosin that is essential in higher organisms.

Keywords: Cancer; Cell migration; GOLPH3; Golgi; MYO18A; Myosin.

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Conflict of interest statement

Conflict of interest

We have no conflicts to report.

Figures

Fig. 1
Fig. 1
Protein domain structure and protein interaction sites of MYO18A. See text for details and references.
Fig. 2
Fig. 2
MYO18A is a critical component of the Golgi GOLPH3 pathway. See text for details and references.
See this image and copyright information in PMC

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