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Review
. 2017 Oct;36(10):1080-1086.
doi: 10.1016/j.healun.2017.07.005. Epub 2017 Jul 15.

Eighth annual INTERMACS report: Special focus on framing the impact of adverse events

James K Kirklin  1 , Francis D Pagani  2 , Robert L Kormos  3 , Lynne W Stevenson  4 , Elizabeth D Blume  5 , Susan L Myers  6 , Marissa A Miller  7 , J Timothy Baldwin  7 , James B Young  8 , David C Naftel  6
Affiliations
Review

Eighth annual INTERMACS report: Special focus on framing the impact of adverse events

James K Kirklin et al. J Heart Lung Transplant. 2017 Oct.

Abstract

Background: The Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database now includes >20,000 patients from >180 hospitals.

Methods: The eighth annual report of INTERMACS updates the first decade of patient enrollment.

Results: In the current era, >95% of implants are continuous flow devices. Overall survival continues to remain >80% at 1 year and 70% at 2 years. Review of major adverse events shows minimal advantage for patients with ambulatory heart failure pre-implant. Stroke, major infection, and continued inotrope requirement during the first 3 months have a major effect on subsequent survival.

Conclusions: Greater application of durable devices to patients with ambulatory heart failure will mandate more effective neutralization or prevention of major adverse events.

Keywords: INTERMACS; advanced heart failure; destination therapy; mechanical support; ventricular assist device.

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