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. 2018 Mar;141(3):1118-1122.e3.
doi: 10.1016/j.jaci.2017.09.002. Epub 2017 Sep 21.

Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A

Jerica Lenberg  1 , Qian Qian  1 , Zehua Sun  1 , Rafeul Alam  2 , Magdalena M Gorska  3
Affiliations

Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A

Jerica Lenberg et al. J Allergy Clin Immunol. 2018 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Pre-pregnancy model. A–F, analysis of pups; G and H, analysis of mothers; A, Total lung resistance, 12–19 pups/group (group description in the main text), the table includes statistical analysis of the resistance data; B, Peribronchial inflammation, 8–15 pups/group; C, BAL cell counts, 11–17 pups/group; D, Cytokine proteins in lung homogenates, 9–12 pups/group; E, Cytokine transcripts in the lung, 8–15 pups/group; F, Cytokine proteins in the BAL fluid, 11–17 pups/group; G and H, Transcripts for cytokines (G) and components of the Ahr pathway (H) in maternal lungs (gestation day 10.5), 6–8 mothers/group; *, P<0.05; **, P<0.01; ***, P<0.001; NS, not significant.
Figure 2
Figure 2
Cytokine depletion. Pups of DEP-exposed females were injected with antibodies against IL1β (A–D; 7–10 mice/group), IL-17A (E–H; 8–12 mice/group) or control IgGs before immunization and again before challenge with OVA. Pups were examined for total lung resistance to methacholine (A, E), peribronchial inflammation (B, F), BAL cell counts (C, G) and pulmonary cytokine transcripts (D, H); Anti-cytokine antibody vs. IgG control: *, P<0.05; **, P<0.01; ***, P<0.001
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