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Case Reports
. 2017 Nov 15;56(22):3089-3092.
doi: 10.2169/internalmedicine.9037-17. Epub 2017 Sep 25.

"Brief" Aripiprazole-induced Neuroleptic Malignant Syndrome with Symptoms that Only Lasted a Few Hours

Naoto Mizumura  1 , Masato Uematsu  2 , Aya Ito  1 , Satoshi Okumura  1 , Hiromitsu Maehira  1 , Masao Ogawa  1 , Masayasu Kawasaki  1
Affiliations
Case Reports

"Brief" Aripiprazole-induced Neuroleptic Malignant Syndrome with Symptoms that Only Lasted a Few Hours

Naoto Mizumura et al. Intern Med. .

Abstract

Neuroleptic malignant syndrome (NMS) with characteristic symptoms is a potentially lethal reaction to antipsychotic drugs. Atypical NMS usually lacks major symptoms and frequently occurs after treatment using atypical antipsychotics, such as aripiprazole. A 64-year-old man developed aripiprazole-induced NMS after surgery, and our early recognition of the NMS was based on high creatine kinase levels and low serum iron levels. His characteristic symptoms (a fever, rigidity, and altered mental status) were only present for a few hours and were resolved by aripiprazole discontinuation and supportive care. Aripiprazole-induced NMS can present with brief but major symptoms, and clinicians may overlook this "brief" appearance of NMS.

Keywords: antipsychotic agents; aripiprazole; early diagnosis; iron; neuroleptic malignant syndrome.

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Figures

Figure.
Figure.
Patient’s clinical course. *Blood pressure approximately equal to the baseline value. Urinary retention was not considered to be present because of the urethral catheter. SBP: systolic blood pressure, HR: heart rate, RR: respiratory rate, POD: postoperative day, WBC: white blood cell count, CK: creatine kinase
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