Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma

Akiko Kojima-Yuasa¹, Xuedan Huang², Isao Matsui-Yuasa³

Affiliations

¹ Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. kojima@life.osaka-cu.ac.jp.
² Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirogane, Minato-ku, Tokyo 108-8641, Japan. kouse@platinum.pharm.kitasato-u.ac.jp.
³ Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. yuasa-i@hotmail.co.jp.

PMID: 28943624
PMCID: PMC5548258
DOI: 10.3390/diseases3040260

Review

Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma

Akiko Kojima-Yuasa et al. Diseases. 2015.

. 2015 Oct 22;3(4):260-281.

doi: 10.3390/diseases3040260.

Authors

Akiko Kojima-Yuasa¹, Xuedan Huang², Isao Matsui-Yuasa³

Affiliations

¹ Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. kojima@life.osaka-cu.ac.jp.
² Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirogane, Minato-ku, Tokyo 108-8641, Japan. kouse@platinum.pharm.kitasato-u.ac.jp.
³ Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan. yuasa-i@hotmail.co.jp.

PMID: 28943624
PMCID: PMC5548258
DOI: 10.3390/diseases3040260

Abstract

Hepatocellular carcinoma (HCC) is highly resistant to currently available chemotherapeutic agents. The clinical outcome of HCC treatment remains unsatisfactory. Therefore, new effective and well-tolerated therapy strategies are needed. Natural products are excellent sources for the development of new medications for disease treatment. Recently, we and other researchers have suggested that the combined effect of natural products may improve the effect of chemotherapy treatments against the proliferation of cancer cells. In addition, many combination treatments with natural products augmented intracellular reactive oxygen species (ROS). In this review we will demonstrate the synergistic anticancer effects of a combination of natural products with chemotherapeutic agents or natural products against human HCC and provide new insight into the development of novel combination therapies against HCC.

Keywords: chemotherapeutic agents; combination treatment; hepatocellular carcinoma (HCC); natural products; reactive oxygen species (ROS); synergistic anticancer effect.

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Conflict of interest statement

The authors declare no conflicts of interest.

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Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma

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Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma

Authors

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Conflict of interest statement

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