Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct;14(4):4231-4236.
doi: 10.3892/ol.2017.6662. Epub 2017 Jul 25.

Increased expression of BPI fold-containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma

Huanan Wang  1   2 , Dongmei Jiang  1   2 , Wenlu Li  1   2 , Shuang Wang  1   2
Affiliations

Increased expression of BPI fold-containing family A member 1 is associated with metastasis and poor prognosis in human colorectal carcinoma

Huanan Wang et al. Oncol Lett. 2017 Oct.

Abstract

Bactericidal or permeability-increasing protein fold-containing family A member 1 (BPIFA1) has been demonstrated to be involved in inflammatory responses in the upper airway and the progression of non-small cell lung cancer. However, the expression levels of BPIFA1 and its clinical prognostic significance in colorectal carcinoma (CRC) has not yet been elucidated. Reverse transcription-polymerase chain reaction and immunohistochemistry were used to analyze the expression levels of BPIFA1 in CRC and normal mucosal tissues. The associations between BPIFA1 expression levels and clinicopathological characteristics, and its predictive value for prognosis in CRC, were statistically evaluated as appropriate. The expression levels of BPIFA1 were revealed to be upregulated at the transcriptional and translational levels in CRC tissues, compared with in normal mucosal tissues. A high expression level of BPIFA1 is significantly associated with invasion depth (P=0.040), lymph node metastasis (P=0.035) and distant metastasis (P=0.010). Furthermore, Kaplan-Meier analysis indicated that BIPFA1 overexpression is associated with short survival time, and the Cox proportional hazards model of risk analysis indicated that BPIFA1 is an independent prognostic factor for patients with CRC. The results of the present study suggested that BPIFA1 expression is upregulated in CRC tissues, and that an increased expression level of BPIFA1 is associated with tumor invasion, metastasis and poor prognosis, indicating that BPIFA1 may be a potential clinical prognostic predictor and therapeutic target for patients with CRC.

Keywords: BPI fold-containing family A member 1; colorectal carcinoma; invasion; metastasis; prognosis.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The expression levels of BPIFA1 mRNA in paired CRC and adjacent normal tissues investigated by quantitative polymerase chain reaction. BPIFA1, BPI fold-containing family A member 1; CRC, colorectal cancer.
Figure 2.
Figure 2.
Expression level analysis of BPIFA1 protein in normal colorectal mucosa and CRC tissues by immunohistochemistry. (A and B) Negative or weak expression levels of BPIFA1 in normal colorectal mucosa (original magnification, ×200); (C-H) BPIFA1 expression levels in human CRC tissue samples. (C) Negative expression level of BPIFA1 (original magnification, ×200); (D) weak expression level of BPIFA1 (original magnification, ×100); (E) medium expression level of BPIFA1 (original magnification, ×200); (F-H) high expression level of BPIFA1 in CRC tissue samples (original magnification, ×200, ×200 and ×400, respectively). BPIFA1, BPI fold-containing family A member 1; CRC, colorectal cancer.
Figure 3.
Figure 3.
Kaplan-Meier survival analysis for overall survival time in 118 patients with CRC according to the BPIFA1 protein expression levels. BPIFA1, BPI fold-containing family A member 1; CRC, colorectal cancer.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Bernard W. Stewart CPW: World cancer report 2014: IARC. 2014
    1. Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP. Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. J Immunol. 2011;187:382–390. doi: 10.4049/jimmunol.1001769. - DOI - PMC - PubMed
    1. Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol. 2011;178:2159–2167. doi: 10.1016/j.ajpath.2011.01.026. - DOI - PMC - PubMed
    1. Ghafouri B, Kihlström E, Ståhlbom B, Tagesson C, Lindahl M. PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid. Biochem Soc Trans. 2003;31:810–814. doi: 10.1042/bst0310810. - DOI - PubMed
    1. Sayeed S, Nistico L, St Croix C, Di YP. Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection. Infect Immun. 2013;81:285–291. doi: 10.1128/IAI.00500-12. - DOI - PMC - PubMed