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Review
. 2017;4(3):258-262.
doi: 10.1007/s40496-017-0150-2. Epub 2017 Jul 12.

The Future of Periodontal-Systemic Associations: Raising the Standards

P Mark Bartold  1 , Angelo Mariotti  2
Affiliations
Review

The Future of Periodontal-Systemic Associations: Raising the Standards

P Mark Bartold et al. Curr Oral Health Rep. 2017.

Abstract

Purpose of review: Periodontal medicine recognizes a "bidirectional" interaction between periodontitis and systemic conditions. Unfortunately, the facile ability to publish a periodontal-systemic association, regardless of biologic plausibility or rigorous scientific scrutiny, continues without abate.

Recent findings: The increasing number of periodontal-systemic associations corrupts the ability of dentists to distinguish which of the associations are spurious and which are valid.

Summary: The use of a Disease Association Checklist creates a register for rational assessment of current disease associations. However, to diminish the publication of spurious periodontal-systemic observational associations, editors must demand that authors follow Bradford-Hill criteria and the STROBE Statement to ensure a stringent pathway to publication.

Keywords: Bradford Hill criteria; Disease Association Checklist; Periodontal medicine; Periodontal systemic inter-relationships; STROBE Statement.

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Conflict of interest statement

Conflict of Interest

P. Mark Bartold and Angelo Mariotti declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Conventional paradigm of periodontal disease whereby periodontitis arises in systemically susceptible individuals due to a chronic inflammatory reaction to subgingival plaque
Fig. 2
Fig. 2
Inverted paradigm of periodontal disease whereby systemic conditions can influence periodontal status and conversely periodontal status can influence systemic conditions
See this image and copyright information in PMC

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