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. 2017 Sep 20:5:30.
doi: 10.1186/s41038-017-0095-7. eCollection 2017.

A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India

Amol Dhopte  1 , Rahul Bamal  2 , Vinay Kumar Tiwari  3
Affiliations

A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India

Amol Dhopte et al. Burns Trauma. .

Abstract

Background: None of the available mortality predicting models in pediatric burns precisely predicts outcomes in every population. Mortality rates as well as their risk factors vary with regions and among different centers within the regions. The aim of this study was to identify socio-demographic and clinical risk factors for mortality in pediatric burns in an effort to decrease the mortality in these patients.

Methods: A prospective analytical study was conducted in patients up to the age of 18 years admitted for burn injuries in a tertiary care burn center in India from January to December 2014. Clinical and demographic data was collected through questionnaire-interview and patient follow-up during their stay in the hospital. Univariate and multivariate firth logistic regression was used to identify various risk factors for mortality in pediatric burns.

Results: A total of 475 patients were admitted during the study period. Overall mortality was 31.3% (n = 149) in this study. Mean age of the patients who died was 8.68 years. Of the 149 deaths, 74 were males and 75 were females (male to female ratio = 0.98). Mean total body surface area (TBSA) involved of the patients who expired was 62%. Inhalational injury was seen in 15.5% (n = 74) of pediatric burn admissions. Mortality was significantly higher (74.3%) in patients with inhalation injury. Mortality was highest in patients with isolates of Acinetobacter + Klebsiella (58.3%), followed by Pseudomonas + Klebsiella (53.3%), Acinetobacter (31.5%), and Pseudomonas (26.3%) (p < 0.0005). Factors found to be significant on univariate firth analysis were older age, female gender, suicidal burns, higher TBSA, presence of inhalation injury, increased depth of burn, and positive microbial cultures. On multivariate analysis, higher TBSA was identified as an independent risk factor for mortality. The adjusted odds ratios for TBSA involvement was 21.706 (25.1-50%), 136.195 (50.1-75%), and 1019.436 (75.1-100%), respectively.

Conclusion: TBSA is the most important factor predicting mortality in pediatric burns. The higher the TBSA, the higher is the risk of mortality. Other significant risk factors for mortality are female gender, deeper burns, positive wound cultures, and inhalation injury. Risk of mortality was significantly lower in children who belonged to urban areas, nuclear family, who sustained burn injury in the last quarter of the year, and who stayed in the hospital for longer period.

Keywords: India; Microbiological cultures; Mortality; Pediatric burns; Risk factors.

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Conflict of interest statement

Ethics approval and consent to participate

Approval from the Institute Ethics Committee of VMMC & Safdarjung Hospital was obtained before this study.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Effect of TBSA on mortality of pediatric burns. Mortality increases significantly with the increase in TBSA. Mortality rate was 100% in patients with TBSA involvement of >70%. TBSA total body surface area
Fig. 2
Fig. 2
Association between length of stay (LOS) in the hospital and pediatric burn mortality. Mortality was highest in patients with LOS of <1 day (93.33%). Mortality rate was 0% in patients who stayed in the hospital for 21–30 days
Fig. 3
Fig. 3
Mortality rates observed in different quarter of the year. Pediatric burn mortality was lowest (10%) in patients admitted during the last quarter of the year and highest (42.9%) in second quarter of the year (p = <0.001)
See this image and copyright information in PMC

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