Review
doi: 10.1016/0022-3956(87)90106-3.
Search for a gene that predisposes individuals to BPI disorder
Affiliations
- PMID: 2894460
- DOI: 10.1016/0022-3956(87)90106-3
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Review
Search for a gene that predisposes individuals to BPI disorder
J Psychiatr Res.
1987.
Abstract
To determine the role of genetics in bipolar affective disorders it was necessary to have correct diagnoses and large homogenous population(s). To identify a marker linked to the disease two additional factors were important, a correct model for genetic transmission and highly polymorphic DNA markers. With the establishment of a linked marker the aim is to identify the susceptibility gene. Two approaches are the prediction of candidate genes and/or the determination of a physical map of the region.
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