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. 2017 Nov;14(11):1072-1074.
doi: 10.1038/nmeth.4432. Epub 2017 Sep 18.

MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads

Chuan-Le Xiao  1   2   3   4 , Ying Chen  2 , Shang-Qian Xie  1   5 , Kai-Ning Chen  1 , Yan Wang  1 , Yue Han  1   6 , Feng Luo  7 , Zhi Xie  1
Affiliations

MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads

Chuan-Le Xiao et al. Nat Methods. 2017 Nov.

Abstract

We present a tool that combines fast mapping, error correction, and de novo assembly (MECAT; accessible at https://github.com/xiaochuanle/MECAT) for processing single-molecule sequencing (SMS) reads. MECAT's computing efficiency is superior to that of current tools, while the results MECAT produces are comparable or improved. MECAT enables reference mapping or de novo assembly of large genomes using SMS reads on a single computer.

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References

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