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Editorial
. 2017 Nov;147(2):240-242.
doi: 10.1016/j.ygyno.2017.09.015. Epub 2017 Sep 22.

Primum non nocere: Are we ready for POLE testing in endometrial cancer?

Casey M Cosgrove  1 , David E Cohn  1 , Paul J Goodfellow  2
Affiliations
Editorial

Primum non nocere: Are we ready for POLE testing in endometrial cancer?

Casey M Cosgrove et al. Gynecol Oncol. 2017 Nov.
No abstract available

Keywords: Endometrial cancer; Molecular classification; POLE testing.

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References

    1. Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, et al. Integrated genomic characterization of endometrial carcinoma. Nature. 2013;497(7447):67–73. - PMC - PubMed
    1. Billingsley CC, Cohn DE, Mutch DG, Stephens JA, Suarez AA, Goodfellow PJ. Polymerase varepsilon (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing. Cancer. 2015;121(3):386–94. - PMC - PubMed
    1. Church DN, Stelloo E, Nout RA, Valtcheva N, Depreeuw J, Ter Haar N, et al. Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer. J Natl Cancer Inst. 2015;107(1) - PMC - PubMed
    1. Talhouk A, McConechy MK, Leung S, Yang W, Lum A, Senz J, et al. Confirmation of ProMisE: A simple, genomics-based clinical classifier for endometrial cancer. Cancer. 2017 - PubMed
    1. Meng B, Hoang LN, McIntyre JB, Duggan MA, Nelson GS, Lee CH, et al. POLE exonuclease domain mutation predicts long progression-free survival in grade 3 endometrioid carcinoma of the endometrium. Gynecol Oncol. 2014 - PubMed

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