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Review
. 2017:2017:1053617.
doi: 10.1155/2017/1053617. Epub 2017 Aug 30.

The Versatile Effects of Dihydromyricetin in Health

Hongliang Li  1 , Qisheng Li  2 , Zhaowen Liu  1 , Kai Yang  1 , Zhixi Chen  1 , Qilai Cheng  1 , Longhuo Wu  1
Affiliations
Review

The Versatile Effects of Dihydromyricetin in Health

Hongliang Li et al. Evid Based Complement Alternat Med. 2017.

Abstract

Dihydromyricetin is a flavonoid isolated from Ampelopsis grossedentata, which is traditionally used in China. Dihydromyricetin exhibits health-benefiting activities with minimum adverse effects. Dihydromyricetin has been demonstrated to show antioxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose metabolism-regulatory activities. Dihydromyricetin may scavenge ROS to protect against oxidative stress or potentiate ROS generation to counteract cancer cells selectively without any effects on normal cells. However, the low bioavailability of dihydromyricetin limits its potential applications. Recent research has gained positive and promising data. This review will discuss the versatile effects and clinical prospective of dihydromyricetin.

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Figures

Figure 1
Figure 1
The structure of dihydromyricetin (1) and its metabolites (2–8).
See this image and copyright information in PMC

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References

    1. Murakami T., Miyakoshi M., Araho D., et al. Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin. BioFactors. 2004;21(1-4):175–178. doi: 10.1002/biof.552210136. - DOI - PubMed
    1. Ruan L.-P., Yu B.-Y., Fu G.-M., Zhu D.-N. Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. Journal of Pharmaceutical and Biomedical Analysis. 2005;38(3):457–464. doi: 10.1016/j.jpba.2005.01.030. - DOI - PubMed
    1. Cao S.-L., Deng X., Xu P., et al. Highly Efficient Enzymatic Acylation of Dihydromyricetin by the Immobilized Lipase with Deep Eutectic Solvents as Cosolvent. Journal of Agricultural and Food Chemistry. 2017;65(10):2084–2088. doi: 10.1021/acs.jafc.7b00011. - DOI - PubMed
    1. Liu L., Yin X., Wang X., Li X. Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharmaceutical biology. 2017;55(1):657–662. doi: 10.1080/13880209.2016.1266669. - DOI - PMC - PubMed
    1. Tong Q., Hou X., Fang J., et al. Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2015;114:455–461. doi: 10.1016/j.jpba.2015.06.030. - DOI - PubMed