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. 2017 Jan;35(1):38-45.

Feasibility and functional outcomes of children and adolescents undergoing preoperative chemotherapy prior to a limb-sparing procedure or amputation

Angela Meyer Corr  1 , Wei Liu  2 , Michael Bishop  3 , Alberto Pappo  3 , Deo Kumar Srivastava  2 , Michael Neel  4 , Bhaskar Rao  4 , Terry Wilson  1 , Kirsten K Ness  5
Affiliations

Feasibility and functional outcomes of children and adolescents undergoing preoperative chemotherapy prior to a limb-sparing procedure or amputation

Angela Meyer Corr et al. Rehabil Oncol. 2017 Jan.

Abstract

Background: Survivors of lower extremity (LE) malignancies experience functional deficits.

Purpose: The purpose of this prospective clinical trial was to determine feasibility and functional outcomes of adding pre-habilitation during the 10-12 week period prior to a planned surgery to remove the tumor in children and adolescents with a LE sarcoma.

Design: Pilot study.

Setting: St. Jude Children's Research Hospital (SJCRH).

Patients: Participants included 14 individuals between the ages of 8 and 20 years who were diagnosed with a LE sarcoma. Participant outcomes were compared to a control group of 35 individuals treated for osteosarcoma that obtained the same functional assessments but no pre-habilitation.

Intervention: The intervention group received strengthening exercises and mobility training 3 times per week for 30-60 minutes for 10-12 weeks preoperatively.

Measurements: Participants completed the Functional Mobility Assessment (FMA) and measures of strength and range of motion (ROM) of bilateral lower extremities (BLEs) at baseline, after 10-12 weeks of preoperative PT, and at 20-22 weeks.

Results: Twelve participants completed at least 50% of their schedule pre-habilitative sessions. The intervention group scored significantly better on the FMA than the control group at weeks 20-22 (35.6 vs. 25.7, p .0267). No significant difference was found in ROM or strength.

Limitations: Due to this study being a pilot study, the sample size was small. Therefore, we cannot infer generalizability.

Conclusions: Findings suggest that those diagnosed with a LE malignancy awaiting a limb sparing procedure or amputation participate in at least 50% of scheduled PT sessions and benefit from them.

Keywords: Pre-habilitation; adolescents; cancer; exercise; pediatrics; physical therapy; sarcoma.

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