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. 2017 Jul 27;4(3):ofx158.
doi: 10.1093/ofid/ofx158. eCollection 2017 Summer.

Liver Cirrhosis as a Risk Factor for Direct-Acting Antiviral Therapy Failure in Real-Life Hepatitis C Virus/Human Immunodeficiency Virus Coinfection

Christoph Boesecke  1   2 , Patrick Ingiliz  3 , Florian Berger  4 , Thomas Lutz  5 , Knud Schewe  6 , Julian Schulze Zur Wiesch  2   7 , Axel Baumgarten  3 , Stefan Christensen  8 , Jürgen K Rockstroh  1   2 , Stefan Mauss  4 ; GECCO Study Group
Affiliations

Liver Cirrhosis as a Risk Factor for Direct-Acting Antiviral Therapy Failure in Real-Life Hepatitis C Virus/Human Immunodeficiency Virus Coinfection

Christoph Boesecke et al. Open Forum Infect Dis. .

Abstract

Current hepatitis C virus (HCV) treatment guidelines recommend treating HCV/human immunodeficiency virus (HIV)-coinfected individuals similar to HCV-monoinfected individuals. Recently inferior response rates to direct acting antiviral (DAA) therapy in HCV/HIV coinfection have been reported. Our German hepatitis C cohort (GECCO) cohort data show that coinfected patients with liver cirrhosis are less likely to achieve viral eradication.

Keywords: DAA; HCV treatment; HCV/HIV coinfection; chronic hepatitis C.

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Figures

Figure 1.
Figure 1.
Sustained virologic response 12 weeks after end of therapy (SVR12) according to cirrhosis status and CD4 T-cell count (/µL).
See this image and copyright information in PMC

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