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Review
. 2018 Jan;23(1):123-129.
doi: 10.1007/s10741-017-9654-z.

Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

Rodrigo Martins Pereira  1   2 , Rania A Mekary  3   4 , Kellen Cristina da Cruz Rodrigues  1   2 , Chadi Pellegrini Anaruma  1   2 , Eduardo Rochete Ropelle  1   2 , Adelino Sanchez Ramos da Silva  5 , Dennys Esper Cintra  1 , José Rodrigo Pauli  1   2 , Leandro Pereira de Moura  6   7
Affiliations
Review

Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

Rodrigo Martins Pereira et al. Heart Fail Rev. 2018 Jan.

Abstract

Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-α) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway. Given the key role of clusterin in preventing loss of cardiac tissue, modulating the expression and function of this protein carries the potential of improving cardiovascular care in the future.

Keywords: Apolipoprotein J; Apoptosis; Cardiomyocytes; Clusterin; Megalin.

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