Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Dec 1;123(23):4530-4534.
doi: 10.1002/cncr.31033. Epub 2017 Sep 26.

From clinical epidemiology to practice recommendations: Knowledge gaps and uncertainty in the management of anal precancers

Affiliations
Editorial

From clinical epidemiology to practice recommendations: Knowledge gaps and uncertainty in the management of anal precancers

Nicolas Wentzensen et al. Cancer. .

Abstract

We discuss the existing data on anal precancers and demonstrate the impact of evidence gaps and uncertainty on a clinical decision model developed to provide clinical guidance for management of anal precancers.

Keywords: Anal precancer; clinical epidemiology; clinical recommendations; cost effectiveness; uncertainty.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest disclosure: The authors report no conflicts of interest.

Comment on

References

    1. Machalek DA, Poynten M, Jin F, et al. Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol. 2012;13:487–500. - PubMed
    1. Islami F, Ferlay J, Lortet-Tieulent J, Bray F, Jemal A. International trends in anal cancer incidence rates. Int J Epidemiol. 2016 - PubMed
    1. Silverberg MJ, Lau B, Achenbach CJ, et al. Cumulative Incidence of Cancer Among Persons With HIV in North America: A Cohort Study. Ann Intern Med. 2015;163:507–518. - PMC - PubMed
    1. Wentzensen N. Screening for anal cancer: endpoints needed. Lancet Oncol. 2012;13:438–440. - PubMed
    1. Wentzensen N, Arbyn M, Berkhof J, et al. Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice. Int J Cancer. 2017;140:2192–2200. - PubMed

LinkOut - more resources