Preterm birth prevention-Time to PROGRESS beyond progesterone
- PMID: 28949963
- PMCID: PMC5614420
- DOI: 10.1371/journal.pmed.1002391
Preterm birth prevention-Time to PROGRESS beyond progesterone
Abstract
In a Perspective, Jane Norman and Phillip Bennett argue that it is time to explore alternatives to progesterone for preventing preterm birth.
Conflict of interest statement
JEN and PB were co-authors and co-grant holders of the OPPTIMUM study. OPPTIMUM was funded by the Efficacy and Mechanism Evaluation (EME) programme, a Medical Research Council (MRC) and National Institute of Health Research (NIHR) partnership, award number G0700452, revised to 09/800/27. The EME programme is funded by the MRC and NIHR, with contributions from the Chief Scientist Office in Scotland and National Institute for Social Care and Research in Wales. PB is a consultant to and holds shares in ObsEva, which develops drugs for the prevention and/or delay of preterm birth.
Comment on
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Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial.PLoS Med. 2017 Sep 26;14(9):e1002390. doi: 10.1371/journal.pmed.1002390. eCollection 2017 Sep. PLoS Med. 2017. PMID: 28949973 Free PMC article. Clinical Trial.
References
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- Crowther CA, Ashwood P, McPhee AJ, Flenady V, Tran T, Dodd JM, et al. Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial. PLoS Med. 2017;14(9): e1002390 https://doi.org/10.1371/journal.pmed.1002390 - DOI - PMC - PubMed
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- Society for Maternal-Fetal Medicine Publications Committee, with assistance of Vincenzo Berghella. Progesterone and preterm birth prevention: translating clinical trials data into clinical practice. Am J Obstet Gynecol. 2012;206(5):376–86. Epub 2012/05/01. doi: 10.1016/j.ajog.2012.03.010 . - DOI - PubMed
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- Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016;387:2106–16. doi: 10.1016/S0140-6736(16)00350-0 . - DOI - PMC - PubMed
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