Structural Biology: A Force-Sensitive Ion Channel Springs to Life
- PMID: 28950085
- DOI: 10.1016/j.cub.2017.07.065
Structural Biology: A Force-Sensitive Ion Channel Springs to Life
Abstract
The sensations of sound, acceleration and touch are mediated by mechanotransduction channels, which convert mechanical stimuli into electrical responses. The structure of one such channel, NOMPC, was recently solved by cryo-EM, revealing a bundle of helices that may act as coiled springs to transmit the forces that open the channel.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Comment on
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Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.Nature. 2017 Jul 6;547(7661):118-122. doi: 10.1038/nature22981. Epub 2017 Jun 26. Nature. 2017. PMID: 28658211 Free PMC article.
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