Review
doi: 10.1016/0378-1119(87)90233-2.
Conserved 12-bp element downstream from mRNA polyadenylation sites
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- PMID: 2895038
- DOI: 10.1016/0378-1119(87)90233-2
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Review
Conserved 12-bp element downstream from mRNA polyadenylation sites
Gene.
1987.
Abstract
Sequences downstream from the AATAAA motif in a number of cellular and viral transcription units have been compared. A 12-bp conserved element was identified in approximately half of the cases studied, and a consensus sequence TTGANNNTTTTTT was derived from a comparison of 74 such sequences. This element is located immediately (5-20 bp) downstream from the poly(A)-addition site in every case where this is known, and it is suggested that this element may be involved in the cleavage/polyadenylation reaction. This proposal is consistent with published studies on deletion mutants of downstream regions.
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