Review

. 2017 Sep 26;6(4):73.

doi: 10.3390/antiox6040073.

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Miriam Martínez-Huélamo¹, Jose Rodríguez-Morató^{2

3

4}, Anna Boronat^{5

6}, Rafael de la Torre^{7

8

9}

Affiliations

¹ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. mmartinez4@imim.es.
² Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. jrodriguez1@imim.es.
³ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. jrodriguez1@imim.es.
⁴ CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), 15706 Santiago de Compostela, Spain. jrodriguez1@imim.es.
⁵ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. aboronat@imim.es.
⁶ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. aboronat@imim.es.
⁷ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. rtorre@imim.es.
⁸ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. rtorre@imim.es.
⁹ CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), 15706 Santiago de Compostela, Spain. rtorre@imim.es.

PMID: 28954417
PMCID: PMC5745483
DOI: 10.3390/antiox6040073

Review

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Miriam Martínez-Huélamo et al. Antioxidants (Basel). 2017.

. 2017 Sep 26;6(4):73.

doi: 10.3390/antiox6040073.

Authors

Miriam Martínez-Huélamo¹, Jose Rodríguez-Morató^{2

3

4}, Anna Boronat^{5

6}, Rafael de la Torre^{7

8

9}

Affiliations

¹ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. mmartinez4@imim.es.
² Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. jrodriguez1@imim.es.
³ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. jrodriguez1@imim.es.
⁴ CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), 15706 Santiago de Compostela, Spain. jrodriguez1@imim.es.
⁵ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. aboronat@imim.es.
⁶ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. aboronat@imim.es.
⁷ Integrated Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, 08003 Barcelona, Spain. rtorre@imim.es.
⁸ Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, 08003 Barcelona, Spain. rtorre@imim.es.
⁹ CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), 15706 Santiago de Compostela, Spain. rtorre@imim.es.

PMID: 28954417
PMCID: PMC5745483
DOI: 10.3390/antiox6040073

Abstract

Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning.

Keywords: Nrf2; cognitive function; hydroxytyrosol; olive oil; polyphenols; resveratrol; wine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Major biologically active phenolic compounds present in olive oil.

**Figure 2**
Representative examples of wine phenolic compounds with biological activities.

See this image and copyright information in PMC

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Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Affiliations

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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