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Randomized Controlled Trial
. 2018 Mar 14;73(4):484-491.
doi: 10.1093/gerona/glx165.

Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial

Mark A Espeland  1 , Owen Carmichael  2 , Kathleen Hayden  3 , Rebecca H Neiberg  1 , Anne B Newman  4 , Jeffery N Keller  5 , Thomas A Wadden  6 , Stephen R Rapp  3 , James O Hill  7 , Edward S Horton  8 , Karen C Johnson  9 , Lynne Wagenknecht  10 , Rena R Wing  11 ; Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) and Action for Health Movement and Memory Ancillary Study Research Groups
Affiliations
Randomized Controlled Trial

Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial

Mark A Espeland et al. J Gerontol A Biol Sci Med Sci. .

Abstract

Background: Diabetes adversely impacts cognition. Lifestyle change can improve diabetes control and potentially improve cognition. We examined whether weight loss through reduced caloric intake and increased physical activity was associated with slower cognitive aging in older adults with type 2 diabetes mellitus.

Methods: The Look AHEAD randomized controlled clinical trial delivered 10 years of intensive lifestyle intervention (ILI) that yielded long-term weight losses. During 5 years spanning the end of intervention and postintervention follow-up, repeated cognitive assessments were obtained in 1,091 individuals who had been assigned to ILI or a control condition of diabetes support and education (DSE). We compared the means and slopes of scores on cognitive testing over these repeated assessments.

Results: Compared with DSE, assignment to ILI was associated with a -0.082 SD deficit in mean global cognitive function across repeated assessments (p = .010). However, overweight (body mass index [BMI] < 30 kg/m2) ILI participants had 0.099 (95% confidence interval [CI]: -0.006, 0.259) better mean global cognitive function compared with overweight DSE participants, while obese (BMI ≥ 30 kg/m2) ILI participants had -0.117 (-0.185, -0.049) SD worse mean composite cognitive function scores (interaction p = .014) compared to obese DSE participants. For both overweight and obese participants, cognitive decline was marginally (-0.014 SD/y overall) steeper for ILI participants (p = .068), with 95% CI for differences in slopes excluding 0 for measures of attention and memory.

Conclusions: The behavioral weight loss intervention was associated with small relative deficits in cognitive function among individuals who were obese and marginally greater cognitive decline overall compared to control. ClinicalTrials.gov Identifier: NCT00017953.

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References

    1. Morley JE. Diabetes and aging: epidemiologic overview. Clin Geriatr Med. 2008;24:395–405, v. doi:10.1016/j.cger.2008.03.005 - PubMed
    1. Araki A, Ito H. Diabetes mellitus and geriatric syndromes. Geriatr Gerontol Int. 2009;9:105–114. doi:10.1111/j.1447-0594.2008.00495.x - PubMed
    1. Vaughan KL, Mattison JA. Obesity and aging in humans and nonhuman primates: a mini-review. Gerontology. 2016;62:611–617. doi:10.1159/000445800 - PMC - PubMed
    1. The Look AHEAD Research Group. Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control Clin Trials 2003;24:610–628. doi:10.1016/S0197-2456(03)00064-3 - PubMed
    1. The Look AHEAD Research Group. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 2014;2:801–809. doi:10.1007/s00125-017-4253-z - PMC - PubMed

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