Case Reports

. 2018 Jun;59(6):1494-1497.

doi: 10.1080/10428194.2017.1382697. Epub 2017 Sep 28.

Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale

M S Zinter^{1

2}, A Melton^{1

3}, A J Sabnis^{1

4}, C C Dvorak^{1

3}, B M Elicker⁵, H M Nawaytou^{1

6}, R J Kameny^{1

2}, J R Fineman^{1

2}

Affiliations

¹ a Benioff Children's Hospital , University of California , San Francisco , CA , USA.
² b Department of Pediatrics, Division of Critical Care Medicine , University of California , San Francisco , CA , USA.
³ c Department of Pediatrics, Division of Allergy, Immunology, and Blood and Marrow Transplantation , University of California , San Francisco , CA , USA.
⁴ d Department of Pediatrics, Division of Hematology and Oncology , University of California , San Francisco , CA , USA.
⁵ e Department of Radiology , University of California , San Francisco , CA , USA.
⁶ f Department of Pediatrics, Division of Cardiology , University of California , San Francisco , CA , USA.

PMID: 28958195
PMCID: PMC5897181
DOI: 10.1080/10428194.2017.1382697

Case Reports

Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale

M S Zinter et al. Leuk Lymphoma. 2018 Jun.

. 2018 Jun;59(6):1494-1497.

doi: 10.1080/10428194.2017.1382697. Epub 2017 Sep 28.

Authors

M S Zinter^{1

2}, A Melton^{1

3}, A J Sabnis^{1

4}, C C Dvorak^{1

3}, B M Elicker⁵, H M Nawaytou^{1

6}, R J Kameny^{1

2}, J R Fineman^{1

2}

Affiliations

¹ a Benioff Children's Hospital , University of California , San Francisco , CA , USA.
² b Department of Pediatrics, Division of Critical Care Medicine , University of California , San Francisco , CA , USA.
³ c Department of Pediatrics, Division of Allergy, Immunology, and Blood and Marrow Transplantation , University of California , San Francisco , CA , USA.
⁴ d Department of Pediatrics, Division of Hematology and Oncology , University of California , San Francisco , CA , USA.
⁵ e Department of Radiology , University of California , San Francisco , CA , USA.
⁶ f Department of Pediatrics, Division of Cardiology , University of California , San Francisco , CA , USA.

PMID: 28958195
PMCID: PMC5897181
DOI: 10.1080/10428194.2017.1382697

No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement

There are no conflicts of interest.

Figures

**Figure 1. Echocardiogram showing findings typical of pulmonary veno-occlusive disease**
(A) Echocardiographic findings demonstrating right atrial and right ventricular dilation without left atrial dilation. There is also a small pericardial effusion. Tricuspid valve inflow Doppler showed right ventricular systolic pressure estimation of 55 mmHg above the right atrial pressure. Concomitant systemic blood pressure is annotated on the image (100/59 mmHg). (B) Two dimensional echocardiographic image of a moderately dilated inferior vena cava (2 cm). There was no collapse of the IVC with forced inspiration. This is suggestive of a right atrial pressure of 5–10 mmHg.

**Figure 2. Contrast enhanced chest CT showing findings typical of pulmonary veno-occlusive disease**
Axial (A) and sagittal reformatted (B) CT images demonstrate diffuse interlobular septal thickening (black arrows). Also visible are diffuse ground glass opacities and ill-defined centrilobular nodules.

See this image and copyright information in PMC

Cited by

Pulmonary Veno-occlusive Disease that Developed Following Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.
Takeda K, Naito A, Sugiura T, Ishige M, Shikano K, Abe M, Kasai H, Miyakuni S, Yamashita S, Shigeta A, Sakao S, Suzuki T. Takeda K, et al. Intern Med. 2023 Jan 15;62(2):275-279. doi: 10.2169/internalmedicine.9811-22. Epub 2022 Jun 14. Intern Med. 2023. PMID: 35705278 Free PMC article.
Pulmonary Manifestations and Vascular Changes in Pediatric Transplantation-Associated Thrombotic Microangiopathy.
Schoettler ML, Saldana BD, Berkenkamp L, Chonat S, Watkins B, Rotz SJ, Simons D, Graf E, Rossi C, Cheng J, Hammers YA, Rytting H, Williams KM. Schoettler ML, et al. Transplant Cell Ther. 2023 Jan;29(1):45.e1-45.e8. doi: 10.1016/j.jtct.2022.09.026. Epub 2022 Oct 4. Transplant Cell Ther. 2023. PMID: 36202334 Free PMC article.
Pulmonary veno-occlusive disease after respiratory syncytial virus infection in a post hematopoietic stem cell transplantation patient.
Watanabe T, Komori K, Saito S, Uchida E, Kurata T, Kitamura M, Matsui H, Takei K, Ogiso Y, Ohta-Ogo K, Nakazawa Y, Sakashita K. Watanabe T, et al. Blood Cell Ther. 2023 Feb 10;6(1):1-4. doi: 10.31547/bct-2022-005. eCollection 2023 Feb 25. Blood Cell Ther. 2023. PMID: 37324568 Free PMC article.
Pulmonary veno-occlusive disease in childhood-a rare disease not to be missed.
Pfluger M, Humpl T. Pfluger M, et al. Cardiovasc Diagn Ther. 2021 Aug;11(4):1070-1079. doi: 10.21037/cdt-20-320. Cardiovasc Diagn Ther. 2021. PMID: 34527533 Free PMC article. Review.

References

1. Jaccard A, Gachard N, Marin B, et al. Efficacy of L-asparaginase with methotrexate and dexamethasone (AspaMetDex regimen) in patients with refractory or relapsing extranodal NK/T-cell lymphoma, a phase 2 study. Blood. 2011;117(6):1834–1839. - PubMed
1. El-Mallawany NK, Geller L, Bollard CM, et al. Long-term remission in a child with refractory EBV(+) hydroa vacciniforme-like T-cell lymphoma through sequential matched EBV(+)-related allogeneic hematopoietic SCT followed by donor-derived EBV-specific cytotoxic T-lymphocyte immunotherapy. Bone Marrow Transplant. 2011;46(5):759–761. - PMC - PubMed
1. Simonneau G, Gatzoulis MA, Adatia I, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D34–41. - PubMed
1. del Cerro Marin MJ, Sabate Rotes A, Rodriguez Ogando A, et al. Assessing pulmonary hypertensive vascular disease in childhood. data from the spanish registry. Am J Respir Crit Care Med. 2014;190(12):1421–1429. - PubMed
1. Lantuejoul S, Sheppard MN, Corrin B, Burke MM, Nicholson AG. Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A clinicopathologic study of 35 cases. Am J Surg Pathol. 2006;30(7):850–857. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale

Affiliations

Pulmonary veno-occlusive disease in a pediatric hematopoietic stem cell transplant patient: a cautionary tale

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources