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. 1988 Apr 23;1(8591):897-9.
doi: 10.1016/s0140-6736(88)91711-4.

Clinical efficacy of a new, enhanced-potency, inactivated poliovirus vaccine

S E Robertson  1 , H P Traverso, J A Drucker, E Z Rovira, B Fabre-Teste, A Sow, M N'Diaye, M T Sy, F Diouf
Affiliations

Clinical efficacy of a new, enhanced-potency, inactivated poliovirus vaccine

S E Robertson et al. Lancet. .

Abstract

The 1986-87 outbreak of paralytic poliomyelitis in Senegal, with 676 reported cases, provided an opportunity to evaluate the efficacy of an enhanced-potency inactivated poliovirus vaccine (N-IPV) in the Kolda region, where this vaccine has been used since 1980. 89 cases, confirmed to have poliomyelitis with residual paralysis, were enrolled in a case-control study, up to 5 matched controls being obtained for each case. The clinical efficacy for one dose of N-IPV was 36% (95% confidence interval 0%, 67%) and for two doses was 89% (95% CI 62%, 97%).

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