MMP Gene Polymorphisms, MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G, and Ischemic Stroke: A Meta-Analysis

Abstract

Background: Several polymorphisms in the human gene encoding MMP have been investigated for the association with ischemic stroke (IS) in the population, of which the MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G polymorphisms gain more and more attention; however, the results are controversial and ambiguous. We therefore carried out the meta-analysis to yield a valid conclusion.

Methods: The literature database was comprehensively searched to identify potentially eligible reports.

Results: A total of 15 studies with 3237 cases and 3075 controls were included in this meta-analysis.

Conclusions: There was a significant association in MMP-1 -1607 1G/2G and MMP-12 -82 A/G gene polymorphisms, but none was observed in MMP-1 -519 A/G. When a subgroup analysis by ethnicity and HWE, MMP-12 -82 A/G gene polymorphisms may be a risk factor for IS in Europe. In Africa, MMP-1 -1607 1G/2G and MMP-12 -82 A/G also showed a significant effect on IS. Further investigation on a larger sample size of different ethnic populations is needed to confirm the findings.

Keywords: MMP gene polymorphisms; association study; ischemic stroke; meta-analysis.