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. 2017 Sep 30;17(1):255.
doi: 10.1186/s12872-017-0685-0.

Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population

Qi Li  1 , Wenhui Peng  2 , Hailing Li  2 , Jianhui Zhuang  2 , Xuesheng Luo  1 , Yawei Xu  3
Affiliations

Association of the single nucleotide polymorphism in chromosome 9p21 and chromosome 9q33 with coronary artery disease in Chinese population

Qi Li et al. BMC Cardiovasc Disord. .

Abstract

Background: Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.

Methods: All patients came from the east China area and underwent coronary angiography. Rs7025486 and rs1333049 polymorphism were genotyped in 555 patients with CAD and in 480 healthy controls that underwent coronary angiography.

Results: In Chinese population, the rs7025486 genotype in the case group was no significant different than the control group (P = 0.531).Meanwhile, the rs1333049 SNP has statistically significant (P = 0.006), which was the independent risk factors for CAD (OR1.252, P = 0.039), and consistent with the past studies conclusion.

Conclusion: Genotype of rs1333049 on chromosome 9p21, but not rs7025486 on chromosome 9q33, is an independent determinant of the incidence of CAD in Chinese population.

Keywords: Coronary artery disease; Single-nucleotide polymorphisms; rs1333049; rs702548.

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Conflict of interest statement

Ethics approval and consent to participate

This study was approved by the Ethics Committee of No. 113 Hospital of Chinese People’s Liberation Army. All patients gave written informed consent.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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