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. 2017 Sep 29;7(1):12453.
doi: 10.1038/s41598-017-12341-3.

The use of innovative and efficient nanocomposite (magnetic graphene oxide) for the reduction on of Fusarium mycotoxins in palm kernel cake

A A Pirouz  1   2 , J Selamat  3   4 , S Z Iqbal  1 , H Mirhosseini  5 , R Abedi Karjiban  6 , F Abu Bakar  1
Affiliations

The use of innovative and efficient nanocomposite (magnetic graphene oxide) for the reduction on of Fusarium mycotoxins in palm kernel cake

A A Pirouz et al. Sci Rep. .

Abstract

Adsorption plays an important role in the removal of mycotoxins from feedstuffs. The main objective of this study was to investigate the efficacy of using magnetic graphene oxide nanocomposites (MGO) as an adsorbent for the reduction of Fusarium mycotoxins in naturally contaminated palm kernel cake (PKC). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to assess the mycotoxins in animal feed. Target mycotoxins included the zearalenone (ZEA), the fumonisins (FB1 and FB2) and trichothecenes (deoxynivalenol (DON), HT-2 and T-2 toxin). Response surface methodology (RSM) was applied to investigate the effects of time (3-7 h), temperature (30-50 °C) and pH (3-7) on the reduction. The response surface models with (R2 = 0.94-0.99) were significantly fitted to predict mycotoxins in contaminated PKC. Furthermore, the method ensured a satisfactory adjustment of the polynomial regression models with the experimental data except for fumonisin B1 and B2, which decrease the adsorption of magnetic graphene oxide (MGO). The optimum reduction was performed at pH 6.2 for 5.2 h at of 40.6 °C. Under these optimum conditions, reduced levels of 69.57, 67.28, 57.40 and 37.17%, were achieved for DON, ZEA, HT-2, and T-2, respectively.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
TEM and FESEM images of GO and MGO: (a) FESEM of GO, (b) FESEM of MGO, (c) TEM of GO and (d) TEM of MGO.
Figure 2
Figure 2
FTIR spectra of (a) GO, (b) MGO, (c) mycotoxins-loaded magnetic graphene oxide.
Figuree 3
Figuree 3
XRD patterns of (a) GO, (b) MGO.
Figure 4
Figure 4
Response surface plots showing the significant (p < 0.05) interaction effects of reduction of DON (a,b), ZEA (c,d), HT-2 (e,f) and T-2 (g,h).
See this image and copyright information in PMC

References

    1. Afsah‐Hejri L, Jinap S, Hajeb P, Radu S, Shakibazadeh S. A review on mycotoxins in food and feed: Malaysia case study. Comprehensive Reviews in Food Science and Food Safety. 2013;12:629–651. doi: 10.1111/1541-4337.12029. - DOI - PubMed
    1. Biselli S, Hartig L, Wegner H, Hummert C. Analysis of Fusarium toxins using LC-MS-MS. Application to various food and feed matrices. LC-GC North America. 2005;23:404–416.
    1. Signorini M, et al. Exposure assessment of mycotoxins in cow’s milk in Argentin. a. Food and Chemical Toxicology. 2012;50:250–257. doi: 10.1016/j.fct.2011.09.036. - DOI - PubMed
    1. Zain ME. Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society. 2011;15:129–144. doi: 10.1016/j.jscs.2010.06.006. - DOI
    1. Bryden, W. L. Mycotoxin contamination of the feed supply chain: Implications for animal productivity and feed security. Animal Feed Science and Technology173, 134–158, 2011.12.014 (2012).

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