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. 1988 May;85(9):3245-9.
doi: 10.1073/pnas.85.9.3245.

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions

L R Steranka  1 , D C Manning, C J DeHaas, J W Ferkany, S A Borosky, J R Connor, R J Vavrek, J M Stewart, S H Snyder
Affiliations

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions

L R Steranka et al. Proc Natl Acad Sci U S A. 1988 May.

Abstract

Autoradiographic studies localize [3H]bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. [3H]Bradykinin labeling is also observed over myocardial/coronary visceral afferent fibers. The localization of [3H]bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.

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