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Review
. 2017 Oct;37(5):420-424.
doi: 10.1016/j.annpat.2017.06.025. Epub 2017 Sep 28.

[A rare endolaryngeal tumor]

[Article in French]
Carine Ngo  1 , Sébastien Albert  2 , Beatrix Barry  2 , Christiane Copie-Bergman  3 , Anne Couvelard  4 , Muriel Hourseau  4
Affiliations
Review

[A rare endolaryngeal tumor]

[Article in French]
Carine Ngo et al. Ann Pathol. 2017 Oct.

Abstract

We report the case of a 65-year-old woman who presented with a dysphonia. ENT tomography and laryngoscopy showed an endolaryngeal tumoral lesion extended to the right supraglottis. Biopsy of the lesion revealed dense lymphoid infiltrate in the lamina propria, without necrosis or ulceration of the mucosa. The infiltrate showed many CD3+, CD5+, CD4+, CD8+ lymphocytes and plasmocytes. Larger lymphoid cells with cytologic atypia expressed CD56 and cytotoxicity markers such as TIA1 and granzyme B. In situ hybridization for EBV revealed numerous positive cells. The diagnosis of extranodal NK/T cell lymphoma was proposed. The primary laryngeal localization of this disease is exceptionally rare. Heavy admixture of inflammatory cells may mimic inflammatory process and delay the diagnosis.

Keywords: EBV; Extranodal NK/T cell lymphoma; Larynx; Lymphome T/NK extraganglionnaire de type nasal.

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