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. 2018 Jan 5:638:1-6.
doi: 10.1016/j.gene.2017.09.059. Epub 2017 Sep 28.

Autoubiquitination of feline E3 ubiquitin ligase BCA2

Weiran Wang  1 , Meng Qu  1 , Jiawen Wang  2 , Xin Zhang  1 , Haihong Zhang  1 , Jiaxin Wu  1 , Bin Yu  1 , Hui Wu  1 , Wei Kong  3 , Xianghui Yu  4
Affiliations

Autoubiquitination of feline E3 ubiquitin ligase BCA2

Weiran Wang et al. Gene. .

Abstract

BCA2/RNF115/Rabring7 is a RING type E3 ubiquitin ligase that is overexpressed in human breast tumors and is important for regulating breast cancer cell migration. In the present investigation, feline BCA2 (fBCA2) was identified and characterized. Compared with its human counterpart, the fBCA2 cDNA was confirmed to be 918 base pairs in length showing 92.6% consensus and identity positions, encoding a protein of 305 amino acids with 96.7% consensus and 93.1% identity positions. The fBCA2 protein contains a RING domain at the C-terminus, which was found to be essential for its autoubiquitination.

Keywords: Autoubiquitination; E3 ubiquitin ligase; Feline BCA2; RING finger domain.

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