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Review
. 2018 Oct:51:1-13.
doi: 10.1016/j.yfrne.2017.09.001. Epub 2017 Sep 28.

Modeling prenatal opioid exposure in animals: Current findings and future directions

Elizabeth M Byrnes  1 , Fair M Vassoler  2
Affiliations
Review

Modeling prenatal opioid exposure in animals: Current findings and future directions

Elizabeth M Byrnes et al. Front Neuroendocrinol. 2018 Oct.

Abstract

The past decade has seen a drastic rise in the number of infants exposed to opioids in utero. It is unclear what lasting effect this exposure may have on these children. Animal models of prenatal opioid exposure may provide insight into potential areas of vulnerability. The present review summarizes the findings across animal models of prenatal opioid exposure, including exposure to morphine, methadone, buprenorphine, and oxycodone. Details regarding the drug, doses, and duration of treatment, as well as key findings, are summarized in tables with associated references. Finally, significant gaps in the current preclinical literature and future directions are discussed.

Keywords: Buprenorphine; Development; HPA; Methadone; Morphine; Mu receptor; Oxycodone; Postnatal; Transgenerational.

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Figures

Figure 1
Figure 1
The number of scientific publications from 2006–2016 as referenced in PubMed that use the phrase “opioid epidemic” in the title.
See this image and copyright information in PMC

References

    1. Ahmadalipour A, Sadeghzadeh J, Vafaei AA, Bandegi AR, Mohammadkhani R, Rashidy-Pour A. Effects of environmental enrichment on behavioral deficits and alterations in hippocampal BDNF induced by prenatal exposure to morphine in juvenile rats. Neuroscience. 2015;305:372–383. - PubMed
    1. Bagley SM, Wachman EM, Holland E, Brogly SB. Review of the assessment and management of neonatal abstinence syndrome. Addict Sci Clin Pract. 2014;9(1):19. - PMC - PubMed
    1. Baldacchino A, Arbuckle K, Petrie DJ, McCowan C. ldquo;Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis. BMC Psychiatry. 2014;14:104. - PMC - PubMed
    1. Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci. 1984;7:309–338. - PubMed
    1. Basheer R, Yang J, Tempel A. Chronic prenatal morphine treatment decreases G alpha s mRNA levels in neonatal frontal cortex. Brain Res Dev Brain Res. 1992;70(1):145–148. - PubMed

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