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Review
. 2018 Jul 5:469:98-106.
doi: 10.1016/j.mce.2017.09.032. Epub 2017 Sep 28.

MENIN loss as a tissue-specific driver of tumorigenesis

Janet W Y Li  1 , Xianxin Hua  2 , Diane Reidy-Lagunes  3 , Brian R Untch  4
Affiliations
Review

MENIN loss as a tissue-specific driver of tumorigenesis

Janet W Y Li et al. Mol Cell Endocrinol. .

Abstract

The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities in tumors with MENIN loss.

Keywords: MEN1; MENIN; Multiple endocrine neoplasia type 1; Pancreatic neuroendocrine tumor; Tumor suppressor gene.

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Figures

Figure 1:
Figure 1:
MEN1 mutations in cancers Aggregation of singular studies and TCGA analyses demonstrates that MEN1 mutations are relatively infrequent in cancers with the exception of pancreatic neuroendocrine tumors and parathyroid adenomas (cbiportal.org).
Figure 2.
Figure 2.
A. MEN1 is on chromosome 11q13.1. It spans 2.8kb and is 610 amino acids long. B. MEN1 mutations are spread diffusely across the entire gene with certain mutations occurring with slightly higher frequency than others (cbioportal.org). (Green dot: missense mutation, black dot: truncating mutation)
See this image and copyright information in PMC

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